Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3–Mediated Indian Hedgehog Signaling
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چکیده
منابع مشابه
Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes
Neural EGFL like 1 (Nell-1) is essential for chondrogenic differentiation, maturation, and regeneration. Our previous studies have demonstrated that Nell-1's pro-chondrogenic activities are predominantly reliant upon runt-related transcription factor 3 (Runx3)-mediated Indian hedgehog (Ihh) signaling. Here, we identify the nuclear factor of activated T-cells 1 (Nfatc1) as the key transcriptiona...
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BACKGROUND Microglia, the resident immune cells of the brain, undergo rapid proliferation and produce several proinflammatory molecules and nitric oxide (NO) when activated in neuropathological conditions. Runx1t1 (Runt-related transcription factor 1, translocated to 1) has been implicated in recruiting histone deacetylases (HDACs) for transcriptional repression, thereby regulating cell prolife...
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www.sciencemag.org (this information is current as of July 23, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/317/5836/372 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/317/5836/372/DC1 can be found a...
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Although most carcinomas arise from a series of genetic alterations in epithelial cells, cancer is a disease that affects not just the transformed cells themselves, but the entire tissue. During tumor development, reciprocal signaling patterns between the cancer cells and the surrounding tissue are altered in a way that affects tissue architecture and cell fate (1). As a result of signals deriv...
متن کاملHedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein.
Hedgehog (Hh) is a member of a family of secreted proteins that direct patterning at multiple stages in both Drosophila and vertebrate development. During Drosophila embryogenesis, Hh protein is secreted by the cells of the posterior compartment of each segment. hh activates transcription of wingless (wg), gooseberry (gsb), and patched (ptc) in the cells immediately adjacent to Hh-secreting cel...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2018
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2017.09.020